Home » Oncogenes Meet Metabolism from Deregulated Genes to a Broader Understanding of Tumour Physiology. Ernst Schering Foundation Symposium Proceedings. by G. Kroemer
Oncogenes Meet Metabolism from Deregulated Genes to a Broader Understanding of Tumour Physiology. Ernst Schering Foundation Symposium Proceedings. G. Kroemer

Oncogenes Meet Metabolism from Deregulated Genes to a Broader Understanding of Tumour Physiology. Ernst Schering Foundation Symposium Proceedings.

G. Kroemer

Published
ISBN : 9781281862495
ebook
274 pages
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 About the Book 

In 1920s, Otto Warburg described the phenomenon of a aerobic glycolysisa (TM), the ability of tumour cells to convert glucose to lactate in the presence of normal oxygen conditions. Warburga (TM)s hypothesis of an altered metabolism in cancer cellsMoreIn 1920s, Otto Warburg described the phenomenon of a aerobic glycolysisa (TM), the ability of tumour cells to convert glucose to lactate in the presence of normal oxygen conditions. Warburga (TM)s hypothesis of an altered metabolism in cancer cells found no immediate acceptance, though it was latter confirmed for most human tumours. With the advent of molecular biology the focus in tumour research has shifted towards the search for oncogenes. However, the interest in cancer molecular profiling eventually led to a renaissance of the Warburg effect trying to combine genetic alterations with effects on metabolism with the help of modern analytic technologies to rapidly analyze broad varieties of metabolites in various tissues and bodyfluids (metabonomics).